4436 A CONTENT ANALYSIS OF CTSA WEBSITES: THE IDENTIFICATION AND EVALUATION OF CTSA PROGRAM HUB WEBSITE CONTENT STANDARDS FOR KNOWLEDGE MANAGEMENT OF NCATS CTSA PROGRAM GOALS AND INITIATIVES

4436 A Content Analysis of CTSA Websites: The Identification and Evaluation of CTSA Program Hub Website Content Standards for Knowledge Management of NCATS CTSA Program Goals and Initiatives

OBJECTIVES/GOALS: Introduction: Between 2014 and 2019 the National Institute of Health (NIH) through the National Center for the Advancement of Translational Science (NCATS) has awarded about $2.7 billion to U.S.Academic Medical Centers to build a national network of clinical and translational science program hubs that serve to meet their key goals

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Behavior of solvent-exposed hydrophobic groove in the anti-apoptotic Bcl-XL protein: clues for its ability to bind diverse BH3 ligands from MD simulations.

Bcl-XL is a member of Bcl-2 family of proteins involved in the regulation of intrinsic pathway of apoptosis.Its overexpression in many human cancers makes it an important target for anti-cancer drugs.Bcl-XL interacts with the BH3 domain of several pro-apoptotic Bcl-2 partners.This helical bundle protein has a pronounced hydrophobic groove which act

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A Spatiotemporal Fuzzy Modeling Approach Combining Automatic Clustering and Hierarchical Extreme Learning Machines for Distributed Parameter Systems

Modeling distributed parameter systems (DPSs) is challenging due to their strong Turntable nonlinearity and spatiotemporal coupling.In this study, a three-dimensional fuzzy modeling method combining genetic algorithm (GA)-based automatic clustering and hierarchical extreme learning machine (HELM) is proposed for DPS modeling.The method utilizes GA-

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